α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced pa...
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibility of nigrostriatal dopamine (DA) neurons in L444P GBA heterozy...
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Full title
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
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TN_cdi_doaj_primary_oai_doaj_org_article_213271272ea14b04817b478ead2a71ae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_213271272ea14b04817b478ead2a71ae
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-017-0233-5
