Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human...
Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
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Author / Creator
Belli, Valentina , Matrone, Nunzia , Napolitano, Stefania , Migliardi, Giorgia , Cottino, Francesca , Bertotti, Andrea , Trusolino, Livio , Martinelli, Erika , Morgillo, Floriana , Ciardiello, Davide , De Falco, Vincenzo , Giunta, Emilio Francesco , Bracale, Umberto , Ciardiello, Fortunato and Troiani, Teresa
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, only a small percentage of mCRC patients receive clinical benefits from anti-EGFR therapies, due to the development of resistance mechanisms. I...
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Full title
Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
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TN_cdi_doaj_primary_oai_doaj_org_article_2140b1307dbb4f399e9a47c0af881d05
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2140b1307dbb4f399e9a47c0af881d05
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-019-1230-z
