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ArticlesPeer ReviewedFull Text
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
Author / Creator:Behan, Fiona M. ; Iorio, Francesco ; Picco, Gabriele ; Gonçalves, Emanuel ; Beaver, Charlotte M. ; Migliardi, Giorgia ; Santos, Rita ; Rao, Yanhua ; Sassi, Francesco ; Pinnelli, Marika ; Ansari, Rizwan ; Harper, Sarah ; Jackson, David Adam ; McRae, Rebecca ; Pooley, Rachel ; Wilkinson, Piers ; van der Meer, Dieudonne ; Dow, David ; Buser-Doepner, Carolyn ; Bertotti, Andrea ; Trusolino, Livio ; Stronach, Euan A. ; Saez-Rodriguez, Julio ; Yusa, Kosuke ; Garnett, Mathew J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-04, Vol.568 (7753), p.511-516
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ArticlesPeer ReviewedFull Text
Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas
Author / Creator:Pignochino, Ymera ; Sarotto, Ivana ; Peraldo-Neia, Caterina ; Penachioni, Junia Y ; Cavalloni, Giuliana ; Migliardi, Giorgia ; Casorzo, Laura ; Chiorino, Giovanna ; Risio, Mauro ; Bardelli, Alberto ; Aglietta, Massimo ; Leone, Francesco
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2010-11, Vol.10 (1), p.631-631, Article 631
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ArticlesPeer ReviewedFull Text
Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer
Author / Creator:Peraldo-Neia, Caterina ; Migliardi, Giorgia ; Mello-Grand, Maurizia ; Montemurro, Filippo ; Segir, Raffaella ; Pignochino, Ymera ; Cavalloni, Giuliana ; Torchio, Bruno ; Mosso, Luciano ; Chiorino, Giovanna ; Aglietta, Massimo
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2011-01, Vol.11 (1), p.31-31, Article 31
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ArticlesPeer ReviewedFull Text
Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
Author / Creator:Pignochino, Ymera ; Grignani, Giovanni ; Cavalloni, Giuliana ; Motta, Manuela ; Tapparo, Marta ; Bruno, Stefania ; Bottos, Alessia ; Gammaitoni, Loretta ; Migliardi, Giorgia ; Camussi, Giovanni ; Alberghini, Marco ; Torchio, Bruno ; Ferrari, Stefano ; Bussolino, Federico ; Fagioli, Franca ; Picci, Piero ; Aglietta, Massimo
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2009-12, Vol.8 (1), p.118-118
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ArticlesPeer ReviewedFull Text
Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
Author / Creator:Belli, Valentina ; Matrone, Nunzia ; Napolitano, Stefania ; Migliardi, Giorgia ; Cottino, Francesca ; Bertotti, Andrea ; Trusolino, Livio ; Martinelli, Erika ; Morgillo, Floriana ; Ciardiello, Davide ; De Falco, Vincenzo ; Giunta, Emilio Francesco ; Bracale, Umberto ; Ciardiello, Fortunato ; Troiani, Teresa
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2019-06, Vol.38 (1), p.236-14, Article 236
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ArticlesPeer ReviewedFull Text
Transfer of 4-hydroxynonenal, a inhibitory hemozoin (HZ) product, from HZ or HZ-laden phagocytes to developing human erythroid cells. A model for erythropoiesis inhibition in malaria anemia
Author / Creator:Skorokhod, Oleksii A ; Caione, Luisa ; Migliardi, Giorgia ; Barrera, Valentina ; Piacibello, Wanda ; Schwarzer, Evelin ; Arese, Paolo
Publisher:London: BioMed Central
Journal title:Malaria journal, 2010-10, Vol.9 (S2), p.1-028, Article O28
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ArticlesPeer ReviewedFull Text
The genomic landscape of response to EGFR blockade in colorectal cancer
Author / Creator:Bertotti, Andrea ; Papp, Eniko ; Jones, Siân ; Adleff, Vilmos ; Anagnostou, Valsamo ; Lupo, Barbara ; Sausen, Mark ; Phallen, Jillian ; Hruban, Carolyn A. ; Tokheim, Collin ; Niknafs, Noushin ; Nesselbush, Monica ; Lytle, Karli ; Sassi, Francesco ; Cottino, Francesca ; Migliardi, Giorgia ; Zanella, Eugenia R. ; Ribero, Dario ; Russolillo, Nadia ; Mellano, Alfredo ; Muratore, Andrea ; Paraluppi, Gianluca ; Salizzoni, Mauro ; Marsoni, Silvia ; Kragh, Michael ; Lantto, Johan ; Cassingena, Andrea ; Li, Qing Kay ; Karchin, Rachel ; Scharpf, Robert ; Sartore-Bianchi, Andrea ; Siena, Salvatore ; Diaz, Luis A. ; Trusolino, Livio ; Velculescu, Victor E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-10, Vol.526 (7572), p.263-267
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ArticlesPeer ReviewedFull Text
HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib
Author / Creator:Valabrega, Giorgio ; Capellero, Sonia ; Cavalloni, Giuliana ; Zaccarello, Gianluca ; Petrelli, Annalisa ; Migliardi, Giorgia ; Milani, Andrea ; Peraldo-Neia, Caterina ; Gammaitoni, Loretta ; Sapino, Anna ; Pecchioni, Carla ; Moggio, Aldo ; Giordano, Silvia ; Aglietta, Massimo ; Montemurro, Filippo
Publisher:Boston: Springer US
Journal title:Breast cancer research and treatment, 2011-11, Vol.130 (1), p.29-40
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ArticlesPeer ReviewedFull Text
Epidermal growth factor receptor
Author / Creator:Pignochino, Ymera ; Montemurro, Filippo ; Peraldo-Neia, Caterina ; Cavalloni, Giuliana ; Migliardi, Giorgia ; Mello-Grand, Maurizia ; Aglietta, Massimo ; Chiorino, Giovanna ; Segir, Raffaella ; Torchio, Bruno ; Mosso, Luciano
Publisher:BioMed Central Ltd
Journal title:BMC cancer, 2011-01, Vol.11, p.31
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ArticlesPeer ReviewedFull Text
Discovery of molecular determinants of response to targeted therapies in colorectal cancer using patient-derived xenografts (‘xenopatients’)
Author / Creator:Sassi, Francesco ; Migliardi, Giorgia ; Zanella, Eugenia ; Galimi, Francesco ; Cottino, Francesca ; Bertotti, Andrea ; Trusolino, Livio
Publisher:London: BioMed Central
Journal title:BMC proceedings, 2013-04, Vol.7 (S2), p.P26-P26, Article P26
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Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

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Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

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Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

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Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

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Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

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Transfer of 4-hydroxynonenal, a inhibitory hemozoin (HZ) product, from HZ or HZ-laden phagocytes to developing human erythroid cells. A model for erythropoiesis inhibition in malaria anemia

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The genomic landscape of response to EGFR blockade in colorectal cancer

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HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib

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Epidermal growth factor receptor

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Discovery of molecular determinants of response to targeted therapies in colorectal cancer using patient-derived xenografts (‘xenopatients’)

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