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Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21d0889ee7df42efac93094fbfb094f9

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

About this item

Full title

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2023-09, Vol.13 (1), p.15500-15500, Article 15500

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder, which poses an evolutionary paradox. Previous research has suggested balanced selection, a mechanism by which schizophrenia risk alleles cou...

Alternative Titles

Full title

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_21d0889ee7df42efac93094fbfb094f9

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21d0889ee7df42efac93094fbfb094f9

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-023-42578-0

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