Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies
Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The natural serotypes of adeno-associated virus (AAV) or their variants, such as AAV8 and AAV5, are commonly used as vectors in the clinical programs for liver-targeted gene therapy. While AAV8 vectors are not highly efficient at targeting primary human hepatocytes, AAV3 vectors have recently demonstrated remarkable efficiency at targeting both hum...
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Full title
Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies
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TN_cdi_doaj_primary_oai_doaj_org_article_21dbdb3102a64787821dc94a450f9501
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21dbdb3102a64787821dc94a450f9501
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-88614-9
