Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-di...
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion
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Author / Creator
Hao, Tianshu , Yu, Jianglong , Wu, Zhida , Jiang, Jie , Gong, Longlong , Wang, Bingjun , Guo, Hanze , Zhao, Huabin , Lu, Bin , Engelender, Simone , He, He and Song, Zhiyin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis. Mitochondria physically and functionally interact with lysosomes to regulate cellular metabolism. Howeve...
Alternative Titles
Full title
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_21df65c007b74e62808b5795885d6a13
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21df65c007b74e62808b5795885d6a13
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39811-9
