A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma
A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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We previously used a pulse-based
assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et al., 2020). Here we advanced this model system and identified a non-genetic mechanism of resistance that drives recovery and regrowth in a subset of cells. Using RNAseq and a suite of bio...
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Full title
A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_2218265a2a26450eb03d27ef3e339032
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2218265a2a26450eb03d27ef3e339032
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.65234
