Adeno-associated virus capsid assembly is divergent and stochastic
Adeno-associated virus capsid assembly is divergent and stochastic
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped
T
= 1 icosahedral capsid of ~3.8 megaDalton, consisting of 60 subunits of 3 distinct viral proteins (VPs), which vary only in their N-terminus. While all three VPs play a role in cell-entry and transduction, their preci...
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Full title
Adeno-associated virus capsid assembly is divergent and stochastic
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TN_cdi_doaj_primary_oai_doaj_org_article_225246aa1453400ca051adc69a713cdf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_225246aa1453400ca051adc69a713cdf
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21935-5
