Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Tropane alkaloids (TAs) are a class of phytochemicals produced by plants of the nightshade family used for treating diverse neurological disorders. Here, we demonstrate de novo production of tropine, a key intermediate in the biosynthetic pathway of medicinal TAs such as scopolamine, from simple carbon and nitrogen sources in yeast (
Saccharomyc...
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Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
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TN_cdi_doaj_primary_oai_doaj_org_article_228fb2896bb7466ebf6688fcfa91ede9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_228fb2896bb7466ebf6688fcfa91ede9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11588-w
