Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation
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Author / Creator
Lee, Chop Yan , Hubrich, Dalmira , Varga, Julia K , Schäfer, Christian , Welzel, Mareen , Schumbera, Eric , Djokic, Milena , Strom, Joelle M , Schönfeld, Jonas , Geist, Johanna L , Polat, Feyza , Gibson, Toby J , Keller Valsecchi, Claudia Isabelle , Kumar, Manjeet , Schueler-Furman, Ora and Luck, Katja
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Structural resolution of protein interactions enables mechanistic and functional studies as well as interpretation of disease variants. However, structural data is still missing for most protein interactions because we lack computational and experimental tools at scale. This is particularly true for interactions mediated by short linear motifs occu...
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Full title
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation
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TN_cdi_doaj_primary_oai_doaj_org_article_22ace84c8c9745df8c5ea1c7bef0edf3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22ace84c8c9745df8c5ea1c7bef0edf3
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ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.1038/s44320-023-00005-6
