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Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22d6864d026e473bab1f5a0e5f21e0cf

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

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Publication information

Publisher

London: Nature Publishing Group UK

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Scope and Contents

Contents

We aimed at identifying the developmental stage at which leukemic cells of pediatric T‐ALLs are arrested and at defining leukemogenic mechanisms based on ATAC‐Seq. Chromatin accessibility maps of seven developmental stages of human healthy T cells revealed progressive chromatin condensation during T‐cell maturation. Developmental stages were distin...

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Full title

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

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Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_22d6864d026e473bab1f5a0e5f21e0cf

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22d6864d026e473bab1f5a0e5f21e0cf

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ISSN

1757-4676

E-ISSN

1757-4684

DOI

10.15252/emmm.202012104

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