Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins
Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Whole-cell cross-linking coupled to mass spectrometry is one of the few tools that can probe protein–protein interactions in intact cells. A very attractive reagent for this purpose is formaldehyde, a small molecule which is known to rapidly penetrate into all cellular compartments and to preserve the protein structure. In light of these benefits,...
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Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins
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TN_cdi_doaj_primary_oai_doaj_org_article_241e25d8cf7443558ebf3920295f87b0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_241e25d8cf7443558ebf3920295f87b0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16935-w