Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational la...
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that adopt stem-loop secondary structures. However, the detailed substrate preferences of APOBEC3A and APOBEC3B hav...
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Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
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TN_cdi_doaj_primary_oai_doaj_org_article_242d0a53917f49e5bc6d9be8d45bb23e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_242d0a53917f49e5bc6d9be8d45bb23e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45909-5
