Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
About this item
Full title
Author / Creator
Chandramohan, Arun , Josien, Hubert , Yuen, Tsz Ying , Duggal, Ruchia , Spiegelberg, Diana , Yan, Lin , Juang, Yu-Chi Angela , Ge, Lan , Aronica, Pietro G. , Kaan, Hung Yi Kristal , Lim, Yee Hwee , Peier, Andrea , Sherborne, Brad , Hochman, Jerome , Lin, Songnian , Biswas, Kaustav , Nestor, Marika , Verma, Chandra S. , Lane, David P. , Sawyer, Tomi K. , Garbaccio, Robert , Henry, Brian , Kannan, Srinivasaraghavan , Brown, Christopher J. , Johannes, Charles W. and Partridge, Anthony W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflows for identifying stapled peptides against Mdm2(X) with in vivo activity and no off-target effects. Key insig...
Alternative Titles
Full title
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Authors, Artists and Contributors
Author / Creator
Josien, Hubert
Yuen, Tsz Ying
Duggal, Ruchia
Spiegelberg, Diana
Yan, Lin
Juang, Yu-Chi Angela
Ge, Lan
Aronica, Pietro G.
Kaan, Hung Yi Kristal
Lim, Yee Hwee
Peier, Andrea
Sherborne, Brad
Hochman, Jerome
Lin, Songnian
Biswas, Kaustav
Nestor, Marika
Verma, Chandra S.
Lane, David P.
Sawyer, Tomi K.
Garbaccio, Robert
Henry, Brian
Kannan, Srinivasaraghavan
Brown, Christopher J.
Johannes, Charles W.
Partridge, Anthony W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_244b34e3aef44b508696598d0927724f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_244b34e3aef44b508696598d0927724f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43346-4
