Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
About this item
Full title
Author / Creator
Van Emburgh, Beth O. , Arena, Sabrina , Siravegna, Giulia , Lazzari, Luca , Crisafulli, Giovanni , Corti, Giorgio , Mussolin, Benedetta , Baldi, Federica , Buscarino, Michela , Bartolini, Alice , Valtorta, Emanuele , Vidal, Joana , Bellosillo, Beatriz , Germano, Giovanni , Pietrantonio, Filippo , Ponzetti, Agostino , Albanell, Joan , Siena, Salvatore , Sartore-Bianchi, Andrea , Di Nicolantonio, Federica , Montagut, Clara and Bardelli, Alberto
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Blockade of the epidermal growth factor receptor (EGFR) with the monoclonal antibodies cetuximab or panitumumab is effective in a subset of colorectal cancers (CRCs), but the emergence of resistance limits the efficacy of these therapeutic agents. At relapse, the majority of patients develop
RAS
mutations, while a subset acquires
EGFR
e...
Alternative Titles
Full title
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Arena, Sabrina
Siravegna, Giulia
Lazzari, Luca
Crisafulli, Giovanni
Corti, Giorgio
Mussolin, Benedetta
Baldi, Federica
Buscarino, Michela
Bartolini, Alice
Valtorta, Emanuele
Vidal, Joana
Bellosillo, Beatriz
Germano, Giovanni
Pietrantonio, Filippo
Ponzetti, Agostino
Albanell, Joan
Siena, Salvatore
Sartore-Bianchi, Andrea
Di Nicolantonio, Federica
Montagut, Clara
Bardelli, Alberto
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_24cf071741ce4d09aa89b3a6aab76cd5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_24cf071741ce4d09aa89b3a6aab76cd5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13665
