Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by...
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells
About this item
Full title
Author / Creator
Gómez-Aleza, Clara , Nguyen, Bastien , Yoldi, Guillermo , Ciscar, Marina , Barranco, Alexandra , Hernández-Jiménez, Enrique , Maetens, Marion , Salgado, Roberto , Zafeiroglou, Maria , Pellegrini, Pasquale , Venet, David , Garaud, Soizic , Trinidad, Eva M. , Benítez, Sandra , Vuylsteke, Peter , Polastro, Laura , Wildiers, Hans , Simon, Philippe , Lindeman, Geoffrey , Larsimont, Denis , Van den Eynden, Gert , Velghe, Chloé , Rothé, Françoise , Willard-Gallo, Karen , Michiels, Stefan , Muñoz, Purificación , Walzer, Thierry , Planelles, Lourdes , Penninger, Josef , Azim, Hatem A. , Loi, Sherene , Piccart, Martine , Sotiriou, Christos and González-Suárez, Eva
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Most breast cancers exhibit low immune infiltration and are unresponsive to immunotherapy. We hypothesized that inhibition of the receptor activator of nuclear factor-κB (RANK) signaling pathway may enhance immune activation. Here we report that loss of RANK signaling in mouse tumor cells increases leukocytes, lymphocytes, and CD8
+
T cells,...
Alternative Titles
Full title
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells
Authors, Artists and Contributors
Author / Creator
Nguyen, Bastien
Yoldi, Guillermo
Ciscar, Marina
Barranco, Alexandra
Hernández-Jiménez, Enrique
Maetens, Marion
Salgado, Roberto
Zafeiroglou, Maria
Pellegrini, Pasquale
Venet, David
Garaud, Soizic
Trinidad, Eva M.
Benítez, Sandra
Vuylsteke, Peter
Polastro, Laura
Wildiers, Hans
Simon, Philippe
Lindeman, Geoffrey
Larsimont, Denis
Van den Eynden, Gert
Velghe, Chloé
Rothé, Françoise
Willard-Gallo, Karen
Michiels, Stefan
Muñoz, Purificación
Walzer, Thierry
Planelles, Lourdes
Penninger, Josef
Azim, Hatem A.
Loi, Sherene
Piccart, Martine
Sotiriou, Christos
González-Suárez, Eva
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_25343e5b801f4662be448798ebe81a76
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25343e5b801f4662be448798ebe81a76
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20138-8
