Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (
) model, we showed that macrophages and microglia respond immediately upon oncogene activation in the brain. Overexpression of human AKT1 within...
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Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
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TN_cdi_doaj_primary_oai_doaj_org_article_255d8380a6f1430295963321963effef
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_255d8380a6f1430295963321963effef
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.31918
