Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation
Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation
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Author / Creator
Kong, Lingling , Hassinan, Cera W , Gerstner, Florian , Buettner, Jannik M , Petigrow, Jeffrey B , Valdivia, David O , Chan-Cortés, Michelle H , Mistri, Amy , Cao, Annie , McGaugh, Scott Alan , Denton, Madeline , Brown, Stephen , Ross, Joshua , Schwab, Markus H , Simon, Christian M and Sumner, Charlotte J
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Intercellular communication between axons and Schwann cells is critical for attaining the complex morphological steps necessary for axon maturation. In the early onset motor neuron disease spinal muscular atrophy (SMA), many motor axons are not ensheathed by Schwann cells nor grow sufficiently in radial diameter to become myelinated. These developm...
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Full title
Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation
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TN_cdi_doaj_primary_oai_doaj_org_article_25c45114ba4f4f2080e24d582bef0dda
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25c45114ba4f4f2080e24d582bef0dda
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-023-01551-8
