CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neu...
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
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Author / Creator
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States) , Wu, Gong-Her , Smith-Geater, Charlene , Galaz-Montoya, Jesús G. , Gu, Yingli , Gupte, Sanket R. , Aviner, Ranen , Mitchell, Patrick G. , Hsu, Joy , Miramontes, Ricardo , Wang, Keona Q. , Geller, Nicolette R. , Hou, Cathy , Danita, Cristina , Joubert, Lydia-Marie , Schmid, Michael F. , Yeung, Serena , Frydman, Judith , Mobley, William , Wu, Chengbiao , Thompson, Leslie M. and Chiu, Wah
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Huntington’s disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripotent stem cells (iPSCs) can help understand disease, defining pathological biomarkers remains challenging. Here, we used cryogenic electron to...
Alternative Titles
Full title
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
Authors, Artists and Contributors
Author / Creator
Wu, Gong-Her
Smith-Geater, Charlene
Galaz-Montoya, Jesús G.
Gu, Yingli
Gupte, Sanket R.
Aviner, Ranen
Mitchell, Patrick G.
Hsu, Joy
Miramontes, Ricardo
Wang, Keona Q.
Geller, Nicolette R.
Hou, Cathy
Danita, Cristina
Joubert, Lydia-Marie
Schmid, Michael F.
Yeung, Serena
Frydman, Judith
Mobley, William
Wu, Chengbiao
Thompson, Leslie M.
Chiu, Wah
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_27dd4928dbf643889186e8bd55e8a97e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_27dd4928dbf643889186e8bd55e8a97e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36096-w
