Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice
Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Rapamycin slows cystogenesis in murine models of polycystic kidney disease (PKD) but failed in clinical trials, potentially due to insufficient drug dosing. To improve drug efficiency without increasing dose, kidney-specific drug delivery may be used. Mesoscale nanoparticles (MNP) selectively target the proximal tubules in rodents. We explored whet...
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Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice
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TN_cdi_doaj_primary_oai_doaj_org_article_280c5588929545ad941f6861d8fa44d3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_280c5588929545ad941f6861d8fa44d3
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-65830-7
