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Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead to cell death when excessive. Here, we show that the ATPase/translocase activity of FANCM keeps telomeric replicative stres...

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

10.1038/s41467-019-10179-z