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Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_29db1d8ce1734f508ff800f6141230b0

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

About this item

Full title

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-01, Vol.9 (1), p.389-11, Article 389

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Fractional killing is the main cause of tumour resistance to chemotherapy. This phenomenon is observed even in genetically identical cancer cells in homogeneous microenvironments. To understand this variable resistance, here we investigate the individual responses to TRAIL in a clonal population of HeLa cells using live-cell microscopy and computat...

Alternative Titles

Full title

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_29db1d8ce1734f508ff800f6141230b0

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_29db1d8ce1734f508ff800f6141230b0

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-017-02787-4

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