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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a266070415e43ab8b818dd620dfebf5

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

About this item

Full title

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-04, Vol.9 (1), p.1393-14, Article 1393

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

In infants intolerant of enteral feeding because of intestinal disease, parenteral nutrition may be associated with cholestasis, which can progress to end-stage liver disease. Here we show the function of hepatic macrophages and phytosterols in parenteral nutrition-associated cholestasis (PNAC) pathogenesis using a mouse model that recapitulates th...

Alternative Titles

Full title

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2a266070415e43ab8b818dd620dfebf5

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a266070415e43ab8b818dd620dfebf5

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-03764-1

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