FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogeno...
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
FMS-like tyrosine kinase 3 (FLT3) in hematopoietic cells binds to its ligand at the plasma membrane (PM), then transduces growth signals.
FLT3
gene alterations that lead the kinase to assume its permanently active form, such as
internal tandem duplication (ITD)
and
D835Y
substitution, are found in 30–40% of acute myelogenous leuke...
Alternative Titles
Full title
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2a9ac2dd3360474c92df8bbb4d4fd572
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a9ac2dd3360474c92df8bbb4d4fd572
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-02221-2
