Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell...
Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn’s disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis (UC). Here, we aimed to study i...
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Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue
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TN_cdi_doaj_primary_oai_doaj_org_article_2b023f1ee744499bbf6487c14fbb9ce2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b023f1ee744499bbf6487c14fbb9ce2
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-31125-x
