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ArticlesPeer ReviewedFull Text
Antimicrobial peptides and gut microbiota in homeostasis and pathology
Author / Creator:Ostaff, Maureen J. ; Stange, Eduard Friedrich ; Wehkamp, Jan
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2013-10, Vol.5 (10), p.1465-1483
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ArticlesPeer ReviewedFull Text
Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide
Author / Creator:Hein, Kyaw Zaw ; Takahashi, Hitoshi ; Tsumori, Toshiko ; Yasui, Yukihiko ; Nanjoh, Yasuko ; Toga, Tetsuo ; Wu, Zhihong ; Grötzinger, Joachim ; Jung, Sascha ; Wehkamp, Jan ; Schroeder, Bjoern O. ; Schroeder, Jens M. ; Morita, Eishin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.13039-13044
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Newsletter articlesFull Text
Genetics and Bowel Diseases; Defense mechanism against bacteria and fungi deciphered
Publisher:Atlanta: NewsRx
Journal title:Obesity, Fitness & Wellness Week, 2011, p.472
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ArticlesPeer ReviewedFull Text
Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action
Author / Creator:Raschig, Judith ; Mailänder-Sánchez, Daniela ; Berscheid, Anne ; Berger, Jürgen ; Strömstedt, Adam A. ; Courth, Lioba F. ; Malek, Nisar P. ; Brötz-Oesterhelt, Heike ; Wehkamp, Jan
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2017-03, Vol.13 (3), p.e1006261-e1006261
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ArticlesPeer ReviewedFull Text
Recent advances and emerging therapies in the non-surgical management of ulcerative colitis [version 1; peer review: 3 approved]
Author / Creator:Wehkamp, Jan ; Stange, Eduard F
Publisher:England: Faculty of 1000 Ltd
Journal title:F1000 research, 2018, Vol.7, p.1207
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ArticlesPeer ReviewedFull Text
Crohn’s disease-derived monocytes fail to induce Paneth cell defensins
Author / Creator:Courth, Lioba F. ; Ostaff, Maureen J. ; Mailänder-Sánchez, Daniela ; Malek, Nisar P. ; Stange, Eduard F. ; Wehkamp, Jan
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14000-14005
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ArticlesPeer ReviewedFull Text
Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases
Author / Creator:Wehkamp, Jan
Publisher:London: BioMed Central
Journal title:Journal of translational medicine, 2011-11, Vol.9 (S2), p.I14-I14, Article I14
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ArticlesPeer ReviewedFull Text
Reduced Paneth Cell α-Defensins in Ileal Crohn's Disease
Author / Creator:Jan Wehkamp ; Salzman, Nita H. ; Edith Porter ; Sabine Nuding ; Michael Weichenthal ; Robert E. Petras ; Shen, Bo ; Elke Schaeffeler ; Matthias Schwab ; Rose Linzmeier ; Ryan W. Feathers ; Hiutung Chu ; Heriberto Lima, Jr ; Klaus Fellermann ; Ganz, Tomas ; Stange, Eduard F. ; Bevins, Charles L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (50), p.18129-18134
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ArticlesPeer ReviewedFull Text
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon
Author / Creator:Peyrin-Biroulet, Laurent ; Beisner, Julia ; Wang, Guoxing ; Nuding, Sabine ; Oommen, Sajit Thottathil ; Kelly, Denise ; Parmentier-Decrucq, Erika ; Dessein, Rodrigue ; Merour, Emilie ; Chavatte, Philipe ; Grandjean, Teddy ; Bressenot, Aude ; Desreumaux, Pierre ; Colombel, Jean-Frédéric ; Desvergne, Béatrice ; Stange, Eduard F ; Wehkamp, Jan ; Chamaillard, Mathias
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (19), p.8772-8777
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ArticlesPeer ReviewedFull Text
Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue
Author / Creator:Stebe-Frick, Sabrina ; Ostaff, Maureen J. ; Stange, Eduard F. ; Malek, Nisar P. ; Wehkamp, Jan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-08, Vol.8 (1), p.12886-11, Article 12886
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ArticlesPeer ReviewedFull Text
Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus
Author / Creator:Stein, Kathy ; Hieggelke, Lena ; Schneiker, Bianca ; Lysson, Mariola ; Stoffels, Burkhard ; Nuding, Sabine ; Wehkamp, Jan ; Kikhney, Judith ; Moter, Annette ; Kalff, Joerg C. ; Wehner, Sven
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-04, Vol.13 (4), p.e0195516-e0195516
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ArticlesPeer ReviewedFull Text
Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo
Author / Creator:Becker, Svetlana ; Oelschlaeger, Tobias A. ; Wullaert, Andy ; Pasparakis, Manolis ; Wehkamp, Jan ; Stange, Eduard F. ; Gersemann, Michael
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-02, Vol.8 (2), p.e55620-e55620
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ArticlesPeer ReviewedFull Text
Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
Author / Creator:Koslowski, Maureen J. ; Kübler, Irmgard ; Chamaillard, Mathias ; Schaeffeler, Elke ; Reinisch, Walter ; Wang, Guoxing ; Beisner, Julia ; Teml, Alexander ; Peyrin-Biroulet, Laurent ; Winter, Stefan ; Herrlinger, Klaus R. ; Rutgeerts, Paul ; Vermeire, Séverine ; Cooney, Rachel ; Fellermann, Klaus ; Jewell, Derek ; Bevins, Charles L. ; Schwab, Matthias ; Stange, Eduard F. ; Wehkamp, Jan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-02, Vol.4 (2), p.e4496-e4496
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ArticlesPeer ReviewedFull Text
GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting
Author / Creator:Schoeler, Marc ; Klag, Thomas ; Wendler, Judith ; Bernhard, Simon ; Adolph, Michael ; Kirschniak, Andreas ; Goetz, Martin ; Malek, Nisar ; Wehkamp, Jan
Publisher:London, England: SAGE Publications
Journal title:Therapeutic advances in gastroenterology, 2018-01, Vol.11, p.1756284818793343-1756284818793343
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ArticlesPeer ReviewedFull Text
Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer
Author / Creator:Huhn, Stefanie ; da Silva Filho, Miguel I. ; Sanmuganantham, Tharmila ; Pichulik, Tica ; Catalano, Calogerina ; Pardini, Barbara ; Naccarati, Alessio ; Polakova-Vymetálkova, Veronika ; Jiraskova, Katerina ; Vodickova, Ludmila ; Vodicka, Pavel ; Löffler, Markus W. ; Courth, Lioba ; Wehkamp, Jan ; Din, Farhat V. N. ; Timofeeva, Maria ; Farrington, Susan M. ; Jansen, Lina ; Hemminki, Kari ; Chang-Claude, Jenny ; Brenner, Hermann ; Hoffmeister, Michael ; Dunlop, Malcolm G. ; Weber, Alexander N. R. ; Försti, Asta
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-06, Vol.13 (6), p.e0199350
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ArticlesPeer ReviewedFull Text
Defective Paneth Cell—Mediated Host Defense in Pediatric Ileal Crohn's Disease
Author / Creator:Perminow, Gøri ; Beisner, Julia ; Koslowski, Maureen ; Lyckander, Lars Gustav ; Stange, Eduard ; Vatn, Morten H ; Wehkamp, Jan
Publisher:Basingstoke: Nature Publishing Group
Journal title:The American journal of gastroenterology, 2010-02, Vol.105 (2), p.452-459
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ArticlesPeer ReviewedFull Text
Recent advances in understanding and managing Crohn’s disease
Author / Creator:Stange, Eduard F. ; Wehkamp, Jan
Publisher:England: Faculty of 1000 Ltd
Journal title:F1000 research, 2016, Vol.5, p.2896-2896
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ArticlesPeer ReviewedFull Text
Gastric Antimicrobial Peptides Fail to Eradicate Helicobacter pylori Infection Due to Selective Induction and Resistance
Author / Creator:Nuding, Sabine ; Gersemann, Michael ; Hosaka, Yoshio ; Konietzny, Sabrina ; Schaefer, Christian ; Beisner, Julia ; Schroeder, Bjoern O. ; Ostaff, Maureen J. ; Saigenji, Katunori ; Ott, German ; Schaller, Martin ; Stange, Eduard F. ; Wehkamp, Jan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-09, Vol.8 (9), p.e73867-e73867
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ArticlesPeer ReviewedFull Text
Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease
Author / Creator:Koslowski, Maureen J. ; Teltschik, Zora ; Beisner, Julia ; Schaeffeler, Elke ; Wang, Guoxing ; Kübler, Irmgard ; Gersemann, Michael ; Cooney, Rachel ; Jewell, Derek ; Reinisch, Walter ; Vermeire, Séverine ; Rutgeerts, Paul ; Schwab, Matthias ; Stange, Eduard F. ; Wehkamp, Jan
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2012-02, Vol.8 (2), p.e1002523-e1002523
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ArticlesPeer ReviewedFull Text
Mechanisms of Disease: defensins in gastrointestinal diseases
Author / Creator:Wehkamp, Jan ; Fellermann, Klaus ; Herrlinger, Klaus R ; Bevins, Charles L ; Stange, Eduard F
Publisher:London: Nature Publishing Group UK
Journal title:Nature clinical practice. Gastroenterology & hepatology, 2005-09, Vol.2 (9), p.406-415
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Antimicrobial peptides and gut microbiota in homeostasis and pathology

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Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

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Genetics and Bowel Diseases; Defense mechanism against bacteria and fungi deciphered

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Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

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Recent advances and emerging therapies in the non-surgical management of ulcerative colitis [version 1; peer review: 3 approved]

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Crohn’s disease-derived monocytes fail to induce Paneth cell defensins

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Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases

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Reduced Paneth Cell α-Defensins in Ileal Crohn's Disease

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Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

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Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue

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Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus

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Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo

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Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

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GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting

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Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer

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Defective Paneth Cell—Mediated Host Defense in Pediatric Ileal Crohn's Disease

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Recent advances in understanding and managing Crohn’s disease

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Gastric Antimicrobial Peptides Fail to Eradicate Helicobacter pylori Infection Due to Selective Induction and Resistance

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Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

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Mechanisms of Disease: defensins in gastrointestinal diseases

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