Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that aging-caused intestinal villus structural and functional decline is regulated by mTORC1, a sensor of nutrients and growth factors, which is highly activated in intestin...
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Full title
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_2b693f1be87a4d81b68d6deb696ecba7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b693f1be87a4d81b68d6deb696ecba7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13911-x
