NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
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Author / Creator
Simoneau, Camille R. , Chen, Pei-Yi , Xing, Galen K. , Hayashi, Jennifer M. , Chen, Irene P. , Khalid, Mir M. , Meyers, Nathan L. , Taha, Taha Y. , Leon, Kristoffer E. , Suryawanshi, Rahul K. , McCavitt-Malvido, Maria , Ashuach, Tal , Fontaine, Krystal A. , Rodriguez, Lauren , Joehnk, Bastian , Walcott, Keith , Vasudevan, Sreelakshmi , Fang, Xiaohui , Maishan, Mazharul , Schultz, Shawn , Roose, Jeroen P. , Matthay, Michael A. , Sil, Anita , Arjomandi, Mehrdad , Yosef, Nir and Ott, Melanie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor (ACE2-OE) that supports robust viral replication while maintaining 3D architect...
Alternative Titles
Full title
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
Authors, Artists and Contributors
Author / Creator
Chen, Pei-Yi
Xing, Galen K.
Hayashi, Jennifer M.
Chen, Irene P.
Khalid, Mir M.
Meyers, Nathan L.
Taha, Taha Y.
Leon, Kristoffer E.
Suryawanshi, Rahul K.
McCavitt-Malvido, Maria
Ashuach, Tal
Fontaine, Krystal A.
Rodriguez, Lauren
Joehnk, Bastian
Walcott, Keith
Vasudevan, Sreelakshmi
Fang, Xiaohui
Maishan, Mazharul
Schultz, Shawn
Roose, Jeroen P.
Matthay, Michael A.
Sil, Anita
Arjomandi, Mehrdad
Yosef, Nir
Ott, Melanie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2b9300e935d0405aa6dbdcaf44fa0f99
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b9300e935d0405aa6dbdcaf44fa0f99
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-66003-2
