Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and...
Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
About this item
Full title
Author / Creator
White, Kevin , Lu, Yu , Annis, Sofia , Hale, Andrew E , Chau, B Nelson , Dahlman, James E , Hemann, Craig , Opotowsky, Alexander R , Vargas, Sara O , Rosas, Ivan , Perrella, Mark A , Osorio, Juan C , Haley, Kathleen J , Graham, Brian B , Kumar, Rahul , Saggar, Rajan , Saggar, Rajeev , Wallace, W Dean , Ross, David J , Khan, Omar F , Bader, Andrew , Gochuico, Bernadette R , Matar, Majed , Polach, Kevin , Johannessen, Nicolai M , Prosser, Haydn M , Anderson, Daniel G , Langer, Robert , Zweier, Jay L , Bindoff, Laurence A , Systrom, David , Waxman, Aaron B , Jin, Richard C and Chan, Stephen Y
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies
in vivo
and promote PH. In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR‐210 and re...
Alternative Titles
Full title
Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
Authors, Artists and Contributors
Author / Creator
Lu, Yu
Annis, Sofia
Hale, Andrew E
Chau, B Nelson
Dahlman, James E
Hemann, Craig
Opotowsky, Alexander R
Vargas, Sara O
Rosas, Ivan
Perrella, Mark A
Osorio, Juan C
Haley, Kathleen J
Graham, Brian B
Kumar, Rahul
Saggar, Rajan
Saggar, Rajeev
Wallace, W Dean
Ross, David J
Khan, Omar F
Bader, Andrew
Gochuico, Bernadette R
Matar, Majed
Polach, Kevin
Johannessen, Nicolai M
Prosser, Haydn M
Anderson, Daniel G
Langer, Robert
Zweier, Jay L
Bindoff, Laurence A
Systrom, David
Waxman, Aaron B
Jin, Richard C
Chan, Stephen Y
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2ba2fa97eac5474ab7e2db24f409a724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2ba2fa97eac5474ab7e2db24f409a724
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201404511
