Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G protein, Rac1, regulate interleukin (IL)17A transcription and autoimmunity. Whereas
Tiam1
genetic deficiency weakens...
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Full title
Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
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TN_cdi_doaj_primary_oai_doaj_org_article_2bd631802f2e4fff88549ccea12edba1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2bd631802f2e4fff88549ccea12edba1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13048
