Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane...
Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-sheet core. The two faces of the...
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Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
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TN_cdi_doaj_primary_oai_doaj_org_article_2c0e9ea1270e440fb213d992e9ac74ae
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2c0e9ea1270e440fb213d992e9ac74ae
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16566-1
