Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach to profile the skeletal muscle transcriptome to exercise and inactivity using 66 published datasets. Data collected from human studies of aerobic and resistance exercise, including acute and chronic exercise training, were integrated using meta-analysis methods (
www.metamex.eu
). Here we use gene ontology and pathway analyses to reveal selective pathways activated by inactivity, aerobic versus resistance and acute versus chronic exercise training. We identify
NR4A3
as one of the most exercise- and inactivity-responsive genes, and establish a role for this nuclear receptor in mediating the metabolic response...
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Full title
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
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TN_cdi_doaj_primary_oai_doaj_org_article_2c2929f8e4044f13af400f8dae2f008f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2c2929f8e4044f13af400f8dae2f008f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13869-w
