Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and tumour progression. ATX has a tripartite active site, combining a hydrophilic groove, a hydrophobic lipid-binding pocket and a...
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Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
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TN_cdi_doaj_primary_oai_doaj_org_article_2ccdbeab88fd47eba8cb69bd11c92811
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2ccdbeab88fd47eba8cb69bd11c92811
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11248
