Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognitio...
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
About this item
Full title
Author / Creator
Stojakovic, Andrea , Trushin, Sergey , Sheu, Anthony , Khalili, Layla , Chang, Su-Youne , Li, Xing , Christensen, Trace , Salisbury, Jeffrey L. , Geroux, Rachel E. , Gateno, Benjamin , Flannery, Padraig J. , Dehankar, Mrunal , Funk, Cory C. , Wilkins, Jordan , Stepanova, Anna , O’Hagan, Tara , Galkin, Alexander , Nesbitt, Jarred , Zhu, Xiujuan , Tripathi, Utkarsh , Macura, Slobodan , Tchkonia, Tamar , Pirtskhalava, Tamar , Kirkland, James L. , Kudgus, Rachel A. , Schoon, Renee A. , Reid, Joel M. , Yamazaki, Yu , Kanekiyo, Takahisa , Zhang, Song , Nemutlu, Emirhan , Dzeja, Petras , Jaspersen, Adam , Kwon, Ye In Christopher , Lee, Michael K. and Trushina, Eugenia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading to neuroprotection in symptomatic APP/PS...
Alternative Titles
Full title
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Authors, Artists and Contributors
Author / Creator
Trushin, Sergey
Sheu, Anthony
Khalili, Layla
Chang, Su-Youne
Li, Xing
Christensen, Trace
Salisbury, Jeffrey L.
Geroux, Rachel E.
Gateno, Benjamin
Flannery, Padraig J.
Dehankar, Mrunal
Funk, Cory C.
Wilkins, Jordan
Stepanova, Anna
O’Hagan, Tara
Galkin, Alexander
Nesbitt, Jarred
Zhu, Xiujuan
Tripathi, Utkarsh
Macura, Slobodan
Tchkonia, Tamar
Pirtskhalava, Tamar
Kirkland, James L.
Kudgus, Rachel A.
Schoon, Renee A.
Reid, Joel M.
Yamazaki, Yu
Kanekiyo, Takahisa
Zhang, Song
Nemutlu, Emirhan
Dzeja, Petras
Jaspersen, Adam
Kwon, Ye In Christopher
Lee, Michael K.
Trushina, Eugenia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2dbe29f2b76b4e27b72c8ee1c521260b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2dbe29f2b76b4e27b72c8ee1c521260b
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-020-01584-y
