Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from...
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a critical role in signal transduction by activating Ras. Here we introduce a single-molecule assay in which individual SOS molecules are captured from raw cell lysate using Ras-functionalized supported membrane microarrays. This enables characterization of the full-length SO...
Alternative Titles
Full title
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2e94ef8418fb45d8a6f011beb41476a4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2e94ef8418fb45d8a6f011beb41476a4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15061
