Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
About this item
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Author / Creator
Soudais, Claire , Schaus, Romane , Bachelet, Camille , Minet, Norbert , Mouasni, Sara , Garcin, Cécile , Souza, Caique Lopes , David, Pierre , Cousu, Clara , Asnagli, Hélène , Parker, Andrew , Palmquist-Gomes, Paul , Sepulveda, Fernando E. , Storck, Sébastien , Meilhac, Sigolène M. , Fischer, Alain , Martin, Emmanuel and Latour, Sylvain
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial
CTPS1
deficiency in humans has previously been shown to lead to immunodeficiency, with impaired expansion of T and B cells. Here, we examine the effects of conditional and inducible inac...
Alternative Titles
Full title
Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice
Authors, Artists and Contributors
Author / Creator
Schaus, Romane
Bachelet, Camille
Minet, Norbert
Mouasni, Sara
Garcin, Cécile
Souza, Caique Lopes
David, Pierre
Cousu, Clara
Asnagli, Hélène
Parker, Andrew
Palmquist-Gomes, Paul
Sepulveda, Fernando E.
Storck, Sébastien
Meilhac, Sigolène M.
Fischer, Alain
Martin, Emmanuel
Latour, Sylvain
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2ee4154d2b4c4068995febb02c537e32
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2ee4154d2b4c4068995febb02c537e32
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45805-y
