Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of three synaptic SNAREs (syntaxin, VAMP2, and SNAP-25) into a four-helix bundle. Catalysis requires fo...
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Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
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TN_cdi_doaj_primary_oai_doaj_org_article_2f2f2bb0b4e54e3b99b0352811480cc3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2f2f2bb0b4e54e3b99b0352811480cc3
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.41771
