Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The interaction between immune cells and phosphatidylserine (PS) molecules exposed on the surface of apoptotic-tumor bodies, such as those induced by chemotherapies, contributes to the formation of an immunosuppressive tumor microenvironment (TME). Annexin A5 (AnxA5) binds with high affinity to PS externalized by apoptotic cells, thereby hindering...
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Full title
Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
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TN_cdi_doaj_primary_oai_doaj_org_article_2fb1fbb0de664cbdac06f9837a479b3c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2fb1fbb0de664cbdac06f9837a479b3c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-14821-z
