Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we present single-particle cryo-electron microscopy structures of
LRRC8A in complex with the inhibitor...
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Full title
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs
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TN_cdi_doaj_primary_oai_doaj_org_article_2fdb45c7a2014b01af29964dd29b4eb1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2fdb45c7a2014b01af29964dd29b4eb1
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.42636
