A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to fe...
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
About this item
Full title
Author / Creator
Zou, Yilong , Palte, Michael J. , Deik, Amy A. , Li, Haoxin , Eaton, John K. , Wang, Wenyu , Tseng, Yuen-Yi , Deasy, Rebecca , Kost-Alimova, Maria , Dančík, Vlado , Leshchiner, Elizaveta S. , Viswanathan, Vasanthi S. , Signoretti, Sabina , Choueiri, Toni K. , Boehm, Jesse S. , Wagner, Bridget K. , Doench, John G. , Clish, Clary B. , Clemons, Paul A. and Schreiber, Stuart L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsic vulnerability to ferroptosis associated with the unique m...
Alternative Titles
Full title
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Authors, Artists and Contributors
Author / Creator
Palte, Michael J.
Deik, Amy A.
Li, Haoxin
Eaton, John K.
Wang, Wenyu
Tseng, Yuen-Yi
Deasy, Rebecca
Kost-Alimova, Maria
Dančík, Vlado
Leshchiner, Elizaveta S.
Viswanathan, Vasanthi S.
Signoretti, Sabina
Choueiri, Toni K.
Boehm, Jesse S.
Wagner, Bridget K.
Doench, John G.
Clish, Clary B.
Clemons, Paul A.
Schreiber, Stuart L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_30381869b6f34533b2be4a86cf0a583a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30381869b6f34533b2be4a86cf0a583a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09277-9
