Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
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United States: Elsevier Inc
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English
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United States: Elsevier Inc
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Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion. We developed antibody-antisense oligonucleotide (AON) conjugates to target and reduce DRR/FAM107A expression. Specifically, we used antibodies against an...
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Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_3056a1b042cd4d40b34479b287633c54
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3056a1b042cd4d40b34479b287633c54
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ISSN
2162-2531
E-ISSN
2162-2531
DOI
10.1016/j.omtn.2018.04.004
