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The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis

The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30f1759d56f94b6dbc7659c15455ac46

The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis

About this item

Full title

The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis

Publisher

England: BioMed Central

Journal title

Acta neuropathologica communications, 2024-02, Vol.12 (1), p.30-5, Article 30

Language

English

Formats

Publication information

Publisher

England: BioMed Central

More information

Scope and Contents

Contents

Recent whole-genome sequencing (WGS) analysis of postmortem brain and spinal cord tissues from ALS/PDC cases did not find evidence for neurogenetic causes (Additional File 1) and results of cryogenic electron microscopy analysis of tau filaments from ALS/PDC cases are in line with an environmental etiologic hypothesis [8]. Next, cells were rinsed w...

Alternative Titles

Full title

The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_30f1759d56f94b6dbc7659c15455ac46

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30f1759d56f94b6dbc7659c15455ac46

Other Identifiers

ISSN

2051-5960

E-ISSN

2051-5960

DOI

10.1186/s40478-024-01725-y

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