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Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31585665f6474631989096c543a84a1e

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

About this item

Full title

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2020-04, Vol.9

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21+/- mice to mimic NUDT21-deletion patients. We found that although th...

Alternative Titles

Full title

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_31585665f6474631989096c543a84a1e

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31585665f6474631989096c543a84a1e

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.50895

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