Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selecti...
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
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England: Taylor & Francis Ltd
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Language
English
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Publisher
England: Taylor & Francis Ltd
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Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like active site of the proteasome, aza-Asp derivatives that were effective inhibitors of caspases-3 and -6,...
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Full title
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_31bf5971d3b54bc09b1c70a575cfb101
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31bf5971d3b54bc09b1c70a575cfb101
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ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2020.1781107
