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ArticlesPeer ReviewedFull Text
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Author / Creator:Oberst, Andrew ; Dillon, Christopher P. ; Weinlich, Ricardo ; McCormick, Laura L. ; Fitzgerald, Patrick ; Pop, Cristina ; Hakem, Razq ; Salvesen, Guy S. ; Green, Douglas R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-03, Vol.471 (7338), p.363-367
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ArticlesPeer ReviewedFull Text
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
Author / Creator:Eckelman, Brendan P ; Salvesen, Guy S ; Scott, Fiona L
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:EMBO reports, 2006-10, Vol.7 (10), p.988-994
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ArticlesPeer ReviewedFull Text
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
Author / Creator:Kasperkiewicz, Paulina ; Poreba, Marcin ; Snipas, Scott J. ; Parker, Heather ; Winterbourn, Christine C. ; Salvesen, Guy S. ; Drag, Marcin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (7), p.2518-2523
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ArticlesPeer ReviewedFull Text
Cell organelles are retained inside pyroptotic corpses during inflammatory cell death
Author / Creator:Hempel, Anne ; D'Osualdo, Andrea ; Snipas, Scott J. ; Salvesen, Guy S.
Publisher:England: Portland Press Ltd The Biochemical Society
Journal title:Bioscience reports, 2023-10, Vol.43 (10), p.1
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ArticlesPeer ReviewedFull Text
IAP proteins: blocking the road to death's door
Author / Creator:Salvesen, Guy S. ; Duckett, Colin S.
Publisher:England: Nature Publishing Group
Journal title:Nature reviews. Molecular cell biology, 2002-06, Vol.3 (6), p.401-410
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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy
Author / Creator:Tom, Irene ; Pham, Victoria C. ; Katschke, Kenneth J. ; Li, Wei ; Liang, Wei-Ching ; Gutierrez, Johnny ; Young, Andrew Ah ; Figueroa, Isabel ; Eshghi, Shadi Toghi ; Lee, ChingWei V. ; Kanodia, Jitendra ; Snipas, Scott J. ; Salvesen, Guy S. ; Lai, Phillip ; Honigberg, Lee ; van Lookeren Campagne, Menno ; Kirchhofer, Daniel ; Baruch, Amos ; Lill, Jennie R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-05, Vol.117 (18), p.9952-9963
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ArticlesPeer ReviewedFull Text
Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates
Author / Creator:Kumar, Sonu ; van Raam, Bram J. ; Salvesen, Guy S. ; Cieplak, Piotr
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-10, Vol.9 (10), p.e110539-e110539
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ArticlesPeer ReviewedFull Text
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
Author / Creator:Avrutsky, Maria I. ; Ortiz, Crystal Colón ; Johnson, Kendra V. ; Potenski, Anna M. ; Chen, Claire W. ; Lawson, Jacqueline M. ; White, Alexandra J. ; Yuen, Stephanie K. ; Morales, Fatima N. ; Canepa, Elisa ; Snipas, Scott ; Salvesen, Guy S. ; Jean, Ying Y. ; Troy, Carol M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-06, Vol.11 (1), p.3173-3173, Article 3173
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ArticlesPeer ReviewedFull Text
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4
Author / Creator:Kasperkiewicz, Paulina ; Poreba, Marcin ; Snipas, Scott J. ; Lin, S. Jack ; Kirchhofer, Daniel ; Salvesen, Guy S. ; Drag, Marcin
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-07, Vol.10 (7), p.e0132818-e0132818
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ArticlesPeer ReviewedFull Text
Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion
Author / Creator:Avrutsky, Maria I. ; Chen, Claire W. ; Lawson, Jacqueline M. ; Snipas, Scott J. ; Salvesen, Guy S. ; Troy, Carol M.
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2023-06, Vol.17, p.1209527
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ArticlesPeer ReviewedFull Text
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
Author / Creator:Lu, Jennifer V. ; Weist, Brian M. ; van Raam, Bram J. ; Marro, Brett S. ; Nguyen, Long V. ; Srinivas, Prathna ; Bell, Bryan D. ; Luhrs, Keith A. ; Lane, Thomas E. ; Salvesen, Guy S. ; Walsh, Craig M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15312-15317
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ArticlesPeer ReviewedFull Text
Structural and kinetic determinants of protease substrates
Author / Creator:Timmer, John C ; Zhu, Wenhong ; Pop, Cristina ; Regan, Tim ; Snipas, Scott J ; Eroshkin, Alexey M ; Riedl, Stefan J ; Salvesen, Guy S
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2009-10, Vol.16 (10), p.1101-1108
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ArticlesPeer ReviewedFull Text
Mitochondrial pathway of apoptosis is ancestral in metazoans
Author / Creator:Bender, Cheryl E. ; Fitzgerald, Patrick ; Tait, Stephen W. G. ; Llambi, Fabien ; McStay, Gavin P. ; Tupper, Douglas O. ; Pellettieri, Jason ; Alvarado, Alejandro Sánchez ; Salvesen, Guy S. ; Green, Douglas R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (13), p.4904-4909
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ArticlesPeer ReviewedFull Text
Emerging principles in protease-based drug discovery
Author / Creator:Drag, Marcin ; Salvesen, Guy S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2010-09, Vol.9 (9), p.690-701
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ArticlesPeer ReviewedFull Text
Caspase Activation: The Induced-Proximity Model
Author / Creator:Salvesen, Guy S. ; Dixit, Vishva M.
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (20), p.10964-10967
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ArticlesPeer ReviewedFull Text
Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum
Author / Creator:Poreba, Marcin ; McGowan, Sheena ; Skinner-Adams, Tina S. ; Trenholme, Katharine R. ; Gardiner, Donald L. ; Whisstock, James C. ; To, Joyce ; Salvesen, Guy S. ; Dalton, John P. ; Drag, Marcin
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e31938-e31938
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ArticlesPeer ReviewedFull Text
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
Author / Creator:Avrutsky, Maria I. ; Ortiz, Crystal Colón ; Johnson, Kendra V. ; Potenski, Anna M. ; Chen, Claire W. ; Lawson, Jacqueline M. ; White, Alexandra J. ; Yuen, Stephanie K. ; Morales, Fatima N. ; Canepa, Elisa ; Snipas, Scott ; Salvesen, Guy S. ; Jean, Ying Y. ; Troy, Carol M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3502-3502, Article 3502
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Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
Author / Creator:Corrigan, Thomas S. ; Lotti Diaz, Leilani M. ; Border, Sarah E. ; Ratigan, Steven C. ; Kasper, Kayla Q. ; Sojka, Daniel ; Fajtova, Pavla ; Caffrey, Conor R. ; Salvesen, Guy S. ; McElroy, Craig A. ; Hadad, Christopher M. ; Doğan Ekici, Özlem
Publisher:England: Taylor & Francis Ltd
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2020-12, Vol.35 (1), p.1387-1402
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ArticlesPeer ReviewedFull Text
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide
Author / Creator:Günther, Saskia D. ; Fritsch, Melanie ; Seeger, Jens M. ; Schiffmann, Lars M. ; Snipas, Scott J. ; Coutelle, Maria ; Kufer, Thomas A. ; Higgins, Paul G. ; Hornung, Veit ; Bernardini, Maria L. ; Höning, Stefan ; Krönke, Martin ; Salvesen, Guy S. ; Kashkar, Hamid
Publisher:London: Nature Publishing Group UK
Journal title:Nature microbiology, 2020-02, Vol.5 (2), p.354-367
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ArticlesPeer ReviewedFull Text
Dimer Formation Drives the Activation of the Cell Death Protease Caspase 9
Author / Creator:Renatus, Martin ; Stennicke, Henning R. ; Scott, Fiona L. ; Liddington, Robert C. ; Salvesen, Guy S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (25), p.14250-14255
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Showing 1 to 20 of 68 results

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

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Cell organelles are retained inside pyroptotic corpses during inflammatory cell death

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IAP proteins: blocking the road to death's door

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

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Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates

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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

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Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

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Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

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Structural and kinetic determinants of protease substrates

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Mitochondrial pathway of apoptosis is ancestral in metazoans

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Emerging principles in protease-based drug discovery

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Caspase Activation: The Induced-Proximity Model

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Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

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Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

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Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

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Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

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Dimer Formation Drives the Activation of the Cell Death Protease Caspase 9

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