GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulat...
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes. However, the impact of individual GRKs on arrestin binding is not clear. We report the creation of eleven combinatorial HEK293 knockout cell clones lacking GRK2/3/5/6, inc...
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GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_330be478d5f2425eb5c6a61f25b74a46
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_330be478d5f2425eb5c6a61f25b74a46
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28152-8
