Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at e...
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo K
estimates are the gold standard for investigating brain drug disposition, animal usage is a limitation to high throughput application. This study investigates an in vitro model using P-gp expressing MDCKII-MDR1 cell...
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Full title
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
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TN_cdi_doaj_primary_oai_doaj_org_article_335b4fcb2320446ba12246e0fb8eecc1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_335b4fcb2320446ba12246e0fb8eecc1
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ISSN
2045-8118
E-ISSN
2045-8118
DOI
10.1186/s12987-023-00495-4
