Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific...
Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
About this item
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Author / Creator
Mendelaar, Pauline A. J. , Smid, Marcel , van Riet, Job , Angus, Lindsay , Labots, Mariette , Steeghs, Neeltje , Hendriks, Mathijs P. , Cirkel, Geert A. , van Rooijen, Johan M. , Ten Tije, Albert J. , Lolkema, Martijn P. , Cuppen, Edwin , Sleijfer, Stefan , Martens, John W. M. and Wilting, Saskia M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of metastasized CRC. Here we present whole genome sequencing data of metastases of 429 CRC patients participating in the pan-cancer CPCT-02 study (NCT01855477). Unsupervised clustering using mutational signature patterns highlights three major patient groups...
Alternative Titles
Full title
Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_33e7a2ece0a048d1b3f265617bf55c52
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_33e7a2ece0a048d1b3f265617bf55c52
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20887-6
