Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intrac...
Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth
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Author / Creator
Dai, Youchao , Zhu, Chuanzhi , Xiao, Wei , Huang, Kaisong , Wang, Xin , Shi, Chenyan , Lin, Dachuan , Zhang, Huihua , Liu, Xiaoqian , Peng, Bin , Gao, Yi , Liu, Cui Hua , Ge, Baoxue , Kaufmann, Stefan He , Feng, Carl G , Chen, Xinchun and Cai, Yi
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor coactivator 4 (NCOA4) was recently identified as a cargo receptor in ferritin degradation. Here, we show that Mtb infection enhanced NCOA4-mediated ferritin degradation in macro...
Alternative Titles
Full title
Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3478bdbf22844e8aa84990870d3c58ed
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3478bdbf22844e8aa84990870d3c58ed
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI159941
