mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
About this item
Full title
Author / Creator
Huang, Hong , Ouyang, Qinqin , Zhu, Min , Yu, Haijia , Mei, Kunrong and Liu, Rong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The mammalian target of rapamycin (mTORC1) has been shown to regulate autophagy at different steps. However, how mTORC1 regulates the N-ethylmaleimide-sensitive protein receptor (SNARE) complex remains elusive. Here we show that mTORC1 inhibits formation of the SNARE complex (STX17-SNAP29-VAMP8) by phosphorylating VAMP8, thereby blocking autophagos...
Alternative Titles
Full title
mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_34d729342eb24e5ea2c8dc490fe613ff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_34d729342eb24e5ea2c8dc490fe613ff
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26824-5
